HocusLocus, LLC is exploiting a novel regulatory mechanism in which one RNA sequence changes the structure of another RNA sequence. Called structurally interacting RNA or sxRNA, the Tenenbaum Lab at the University at Albany has described how miRNA use this interaction to control protein binding to an mRNA. Broadly speaking, sxRNA provides a method to make an aptamer "switchable", i.e. the aptamer is functional or not as a result of a trans-interaction with a miRNA.
We are using this mechanism both to control translation of an mRNA to achieve the ability to selectively express protein in specific cell types, and to create a new class of miRNA inhibitors.